Kaum yim lub hlis mus rau covid-19 muaj kev kis thoob qhov txhia chaw, nrog rau qhov sib txawv ntawm qhov chaw ua rau muaj kev rov muaj mob loj, ntau lub tsev kho mob tab tom tsoo lub siab tshiab. Lawv nyob tam sim no poob me nyuam rau tus mob coronavirus.

Thawj qhov tshaj tawm covid-cuam tshuam txog kev tuag ntawm tus menyuam mos tau tshwm sim hauv Orange County, Florida, thiab tus menyuam mos tau tuag lawm hauv Mississippi. Lub Nroog Merced hauv California poob ib tug menyuam hnub nyoog qis dua ib xyoos thaum lub Yim Hli lig.

Dr. Paul Offit, tus kws tshaj lij txog kab mob sib kis ntawm Tsev Kho Mob Menyuam Yaus ntawm Philadelphia tau hais tias "Nws nyuaj heev uas yog zoo li lwm lub tsev kho mob menyuam yaus thoob plaws tebchaws.

Txog rau qhov kev hloov pauv ntawm thaj av tau siege lub caij ntuj sov no, yuav luag txhua tus menyuam zoo li raug zam los ntawm kev puas tsuaj loj ntawm covid, vim li cas cov kws tshawb fawb tsis nkag siab kiag li.

Txawm hais tias tsis muaj pov thawj qhov sib txawv ntawm delta ua rau muaj mob hnyav dua, tus kab mob kis tau zoo heev uas cov menyuam tau mus pw hauv tsev kho mob coob - feem ntau nyob hauv cov xeev uas muaj tshuaj tiv thaiv tsawg. Yuav luag 30% ntawm covid tau hais qhia rau lub asthiv uas xaus rau lub Cuaj Hlis 9 yog menyuam yaus, raws li American Academy of Pediatrics.

Cov kws kho mob kuaj mob ntau dua 243,000 tus neeg mob hauv menyuam yaus nyob rau tib lub lim tiam, nqa tag nrho cov kis mob covid hauv cov menyuam hnub nyoog qis dua 18 xyoo txij li pib muaj kev kis thoob qhov txhia chaw 5.3 lab, nrog tsawg kawg 534 tuag.

Cov kws tshaj lij hais tias nws yog lo lus nug ntawm lej yooj yim. "Yog tias muaj 10 zaug ntau tus menyuam tau kis tus kab mob delta dua li cov kev hloov pauv yav dhau los, yog li, peb yuav pom ntau dua 10 tus menyuam nyob hauv tsev kho mob," said Dr. Dimitri Christakis, tus thawj coj ntawm Center for Child Health, Behavior thiab Kev txhim kho ntawm Seattle Cov Menyuam Tshawb Fawb Lub Koom Haum.

Tab sis qhov xwm txheej tam sim no muab qhov xwm txheej tshiab rau cov lus nug uas muaj cov kws tshawb fawb paub tsis thoob thoob qhov kev kis thoob qhov txhia chaw: Dab tsi tiv thaiv menyuam yaus feem ntau los ntawm kev mob hnyav? Thiab vim li cas qhov kev tiv thaiv qee zaum ua tsis tiav?

Dr Bill Kapogiannis, tus kws saib xyuas kev noj qab haus huv laus thiab tus kws tshaj lij kis kab mob ntawm Eunice Kennedy Shriver National Institute of Child Health and Human Development tau hais tias "Qhov no yog lus nug sai thiab nyuaj."

Kapogiannis tau hais tias "Peb ua txhua yam peb tuaj yeem ua tau los daws nws, siv txhua yam cuab yeej peb muaj," "Cov lus teb tsis tuaj sai sai txaus."

Tshawb Nrhiav Lub Cev Muaj Zog

Txog ntau qhov kev mob kis thoob qhov txhia chaw, cov kws kho mob tsuas tuaj yeem kwv yees tias yog vim li cas menyuam yaus lub cev tiv thaiv kab mob thiaj li ua tiav ntau dua ntawm kev tawm tsam tus kabmob coronavirus.

Txawm hais tias muaj pes tsawg tus menyuam yaus pw hauv tsev kho mob tsis ntev los no, cov tub ntxhais hluas tsis tshua muaj mob hnyav. Tsawg dua 1% ntawm cov menyuam kuaj mob nrog covid tau mus pw hauv tsev kho mob thiab kwv yees li 0.01% tuag - tus nqi uas tsis tau hloov pauv nyob rau lub hlis dhau los, raws li American Academy of Pediatrics. Feem ntau cov menyuam yaus yws tawm tus kab mob nrog me ntsis ntau dua li hnia.

Lub cev pov thawj loj zuj zus qhia tias cov menyuam yaus lub cev tiv thaiv kab mob feem ntau nip kev kis tus kab mob thaum ntxov, tiv thaiv tus kab mob los ntawm kev nqis peev thiab txau tsis txheeb xyuas, hais tias Dr. Lael Yonker, tus pab xibfwb qhia txog menyuam yaus ntawm Tsev Kho Mob Massachusetts General.

Hauv cov kev tshawb fawb luam tawm nyob rau xyoo dhau los, pab txiv tsev thiab tus poj niam ntawm Drs. Betsy thiab Kevan Herold pom tias cov menyuam muaj tshwj xeeb muaj zog tiv thaiv mucosal, yog li hu vim tias cov neeg tseem ceeb hauv cov kab ke no tsis nyob hauv cov ntshav tab sis hauv mob ua xas uas kab lub qhov ntswg, caj pas thiab lwm qhov hauv lub cev uas nquag ntsib cov kab mob.

Cov membrane no ua zoo li txheej txheej phab ntsa pob zeb uas tiv thaiv cov nroog hauv nruab nrab los ntawm kev txeeb chaw. Lawv tau ua los ntawm cov hlwb epithelial - cov no kuj yog kab ntau lub cev sab hauv - uas nyob ib sab nrog cov tub rog tseem ceeb hauv lub cev tiv thaiv kab mob hu ua dendritic cells thiab macrophages, hais tias Betsy Herold, tus thawj ntawm kev faib cov menyuam yaus kis mob ntawm Albert Einstein College ntawm Tshuaj.

Qhov tseem ceeb, cov hlwb no tau npog nrog cov protein - hu ua qauv lees paub cov neeg txais khoom - uas ua haujlwm zoo li cov xa khoom, txuas ntxiv tshuaj xyuas toj roob hauv pes rau ib yam dab tsi txawv txav. Thaum cov neeg xa ntawv ceeb toom qee yam txawv teb chaws - zoo li tus kab mob tshiab - lawv ceeb toom cov cell kom pib tso cov protein hu ua interferons, uas pab tswj xyuas lub cev tiv thaiv kab mob.

In kev kawm lub Yim Hli hauv Xwm Biotechnology, Roland Eils thiab nws cov npoj yaig ntawm Lub Tsev Haujlwm Berlin Lub Tsev Haujlwm Saib Xyuas Kev Noj Qab Haus Huv hauv Tebchaws Yelemees pom tias menyuam yaus txoj hlab pa loj yog "ua ntej" kom tua tau tus kabmob tshiab. Lawv txoj kev dav dav tau teeb tsa nrog cov xa no, suav nrog cov uas ua tau zoo ntawm kev lees paub tus kabmob coronavirus.

Qhov ntawd tso cai rau menyuam yaus qhib lawv lub cev tiv thaiv kab mob tam sim ntawd, tso cov interferons uas pab kaw tus kab mob ua ntej nws tuaj yeem tsim lub hauv paus, Eils hais.

Hauv kev sib piv, cov neeg laus muaj tsawg dua tus neeg xa tub ceev xwm saib xyuas thiab siv sijhawm li ob hnub los teb rau tus kabmob, Eils tau hais. Txog lub sijhawm ntawd, tus kabmob tuaj yeem sib kis tau ntau ntxiv, thiab kev sib ntaus sib tua nyuaj dua.

Thaum lub cev tiv thaiv kab mob tsis tiv thaiv tus kab mob, lub cev tuaj yeem rov qab los ntawm lub cev tiv thaiv kab mob hloov pauv, kab thib ob ntawm kev tiv thaiv uas yoog raws txhua qhov kev hem thawj tshwj xeeb. Cov txheej txheem hloov pauv tsim cov tshuaj tiv thaiv kab mob, piv txwv li, haum rau txhua tus kab mob lossis kab mob hauv lub cev.

Thaum cov tshuaj tiv thaiv kab mob yog qee qhov yooj yim tshaj plaws ntawm kev tiv thaiv kab mob los ntsuas, thiab yog li feem ntau raug suav hais tias yog tus tiv thaiv kev tiv thaiv, menyuam tsis zoo li xav tau ntau npaum li tiv thaiv covid, Betsy Herold tau hais. Qhov tseeb, Herolds ' kev tshawb fawb qhia tias cov menyuam yaus nrog covid muaj tsawg dua cov tshuaj tiv thaiv nruab nrab ntau dua li cov neeg laus. (Ob tus menyuam thiab cov neeg laus feem ntau ua cov tshuaj tiv thaiv txaus los tiv thaiv kev kis tus kabmob coronavirus yav tom ntej tom qab kis tus kabmob lossis txhaj tshuaj tiv thaiv.)

Thaum cov txheej txheem tiv thaiv kab mob tuaj yeem ua haujlwm tau zoo, qee zaum nws tuaj yeem ua rau muaj kev phom sij ntau dua li qhov zoo.

Zoo li cov tub rog uas tua lawv cov phooj ywg nrog hluav taws zoo, kev tiv thaiv kev tiv thaiv kab mob tsis zoo tuaj yeem ua rau muaj kev puas tsuaj, ua rau muaj cov kab mob sib kis uas cuam tshuam tsis tsuas yog kis kab mob, tab sis tseem muaj lub zog noj qab haus huv thoob plaws lub cev.

Hauv qee tus neeg mob covid, kev tswj tsis tau tuaj yeem ua rau muaj ntshav txaus rau txoj sia thiab tus yam ntxwv mob RAU TXOJ hlab ua pa uas mob ceev, uas tshwm sim thaum cov kua ua rau hauv cov pa hauv lub ntsws thiab ua rau nws ua pa nyuaj, Betsy Herold tau hais. Ob qho tib si yog qhov ua rau tuag hauv cov neeg laus covid.

Vim tias cov menyuam feem ntau tshem tus kabmob coronavirus sai sai, lawv feem ntau zam qhov kev mob hnyav no, nws hais.

Kev tshawb fawb qhia tias cov menyuam muaj kev noj qab haus huv muaj cov khoom siv ntau ntawm cov neeg saib xyuas kev sib haum xeeb, hu ua innate lymphoid cells, uas pab ua kom lub cev tsis muaj zog tiv thaiv kab mob thiab kho kev puas tsuaj rau lub ntsws, hais tias Dr.

Cov menyuam yaus tau yug los nrog ntau lub cell no, tab sis lawv cov lej poob nrog lub hnub nyoog. Thiab ob tus menyuam thiab cov neeg laus uas mob nrog covid zoo li muaj tsawg dua ntawm cov xovtooj kho no, Luban hais.

Cov txiv neej kuj tseem muaj cov cell kho tsawg dua li poj niam, uas tuaj yeem pab piav qhia tias vim li cas txiv neej thiaj muaj kev pheej hmoo tuag los ntawm covid ntau dua li poj niam.

Ob tus menyuam yaus thiab cov neeg laus tuaj yeem tsim "covid ntev", cov teeb meem kev noj qab haus huv nyob ntev los ntawm 10% ntawm cov neeg hluas thiab nce txog 22% ntawm cov 70 thiab laus dua. Cov kev tshawb fawb qhia tias 4% rau 11% ntawm cov menyuam muaj cov tsos mob tsis tu ncua

Cov Lus Nug uas tsis tau teb

Cov kws tshawb fawb muaj tsawg dua qhov qhia txog qhov ua tsis raug ntawm qee tus menyuam yaus nrog covid, hais tias Kevan Herold, uas qhia kev tiv thaiv kab mob tiv thaiv kab mob ntawm Yale Tsev Kawm Ntawv Tshuaj.

Kev tshawb fawb qhia tias cov menyuam yaus muaj lub cev tiv thaiv kab mob tsis muaj zog ntau dua li cov neeg laus vim tias lawv tau ntsib ntau yam kab mob ua pa tsis ntev los no, hauv lawv thawj ob peb xyoos, uas yuav ua rau lawv lub cev tiv thaiv kab mob rau tom ntej.

Tab sis tsis yog txhua tus menyuam yaus yws tawm covid kom yooj yim, Eils hais. Cov menyuam mos liab tsis tau muaj sia nyob ntev txaus los txhawb lawv lub cev tiv thaiv kev sib ntaus sib tua. Txawm hais tias cov menyuam yaus tuaj yeem ua tsis tau cov lus teb muaj zog, nws hais.

Ntawm Me Nyuam Tsev Kho Mob New Orleans, ib nrab ntawm cov neeg mob covid muaj hnub nyoog qis dua 4, hais tias Dr. Mark Kline, tus kws tshaj lij tshwj xeeb hauv kev kis kab mob thiab kws kho mob-hauv-tus thawj.

Kline tau hais tias "Peb tau muaj menyuam yaus txij li 7 lub lis piam, 9 lub lis piam hauv ICU ntawm lub tshuab ua pa," "Peb muaj hnub nyoog 3-hlis uas xav tau ECMO," lossis cov pa oxygen ntxiv rau lub cev, uas tus neeg mob txuas nrog lub tshuab zoo ib yam li lub plawv-lub ntsws lub tshuab hla kev siv hauv kev phais plawv.

Txawm tias yav dhau los cov menyuam muaj kev noj qab haus huv qee zaum tuag los ntawm kev kis kab mob ua pa, los ntawm covid mus rau mob khaub thuas lossis kab mob ua pa.

Tab sis kev tshawb fawb tau pom qhov ntawd 30% rau 70% ntawm cov menyuam pw hauv tsev kho mob nrog covid muaj cov xwm txheej hauv qab uas ua rau lawv muaj kev pheej hmoo, xws li Down syndrome, rog dhau, mob ntsws, mob ntshav qab zib lossis lub cev tsis muaj zog. Cov menyuam mos yug ntxov tseem muaj kev pheej hmoo siab dua, ib yam li menyuam yaus uas tau dhau los kho mob qog noj ntshav.

Ib yam uas cov menyuam pw hauv tsev kho mob muaj ib yam yog yuav luag tsis tau txhaj tshuaj, hais tias Dr. Mary Taylor, tus kws saib xyuas menyuam yaus ntawm University of Mississippi Medical Center.

Taylor tau hais tias "Tsis muaj txoj hauv kev los paub tus menyuam twg nrog covid yuav mob khaub thuas thiab ua tau zoo thiab tus menyuam twg yuav mob hnyav," Taylor hais. "Nws tsuas yog qhov kev cia siab rau cov tsev neeg zoo li tsis muaj ib yam uas lawv tuaj yeem ua rau lawv tus menyuam."

Txawm hais tias cov kws tshawb fawb tau txheeb xyuas noob caj noob ces txuam nrog covid heev, cov kev hloov pauv no tsis tshua muaj neeg pom.

Cov kws tshawb fawb tau muaj kev ua tiav ntau ntxiv pom qhov laj thawj vim li cas qee tus neeg laus ua rau covid.

Qee qhov xwm txheej ntawm covid hnyav rau cov neeg laus, piv txwv li, tau raug khi rau cov tshuaj tiv thaiv tsis raug uas yog lub hom phiaj interferons, ntau dua li tus mob coronavirus. Kev kawm ntawv lub yim hli ntuj hauv ScienceImmunology tshaj tawm tias xws li "autoantibodies" ua rau 20% ntawm covid tuag.

Autoantibodies tsis tshua muaj tshwm sim hauv cov menyuam yaus thiab cov tub ntxhais hluas, txawm li cas los xij, thiab tsis zoo li yuav piav qhia yog vim li cas qee tus menyuam thiaj li ua rau tus kabmob no, hais tias tus kws tshawb fawb sau Dr.

Txawm tias tsev kho mob tau poob qis thoob tebchaws, qee qhov kev raug mob hnyav tshaj plaws ntawm kev kis tus kab mob tsuas yog tshwm sim tam sim no.

Ob lub hlis mus rau qhov dej ntws hla, cov tsev kho mob thoob plaws Sab Qab Teb tau pom nthwv dej thib ob ntawm cov menyuam uas tsis tshua muaj tab sis muaj kev phom sij rau lub neej hu ua multisystem inflammatory syndrome, lossis MIS-C.

Tsis zoo li cov menyuam yaus uas tsim covid mob ntsws-qhov tseem ceeb ua rau mus pw hauv tsev kho mob ntawm cov menyuam yaus-cov uas muaj MIS-C feem ntau muaj mob me me lossis asymptomatic tab sis mob hnyav txog li ib hlis tom qab, tsim cov tsos mob xws li xeev siab, ntuav, tawm pob, ua npaws thiab raws plab. Qee tus tsim cov ntshav khov thiab ua rau cov ntshav qis txaus ntshai. Ntau dua 4,661 tus menyuam tau kuaj mob MIS-C thiab 41 tus neeg tau tuag, raws li tsab ntawv Cov Chaw rau Kev Tswj Xyuas thiab Tiv Thaiv.

Txawm hais tias cov kws tshawb fawb tseem tsis paub qhov tseeb ntawm MIS-C, kev tshawb fawb los ntawm Yonker ntawm Massachusetts General thiab lwm tus qhia tias cov kab mob kis tau tuaj yeem xau los ntawm lub plab mus rau hauv cov hlab ntshav, ua rau muaj kev tawm tsam thoob plaws lub cev.

Nws tseem ntxov dhau los qhia seb cov menyuam puas muaj sia nyob MIS-C yuav raug teeb meem kev noj qab haus huv nyob ntev, hais tias Dr. Leigh Howard, tus kws tshaj lij kho mob kis menyuam yaus ntawm Vanderbilt University Medical Center.

Txawm hais tias kev kawm lub Yim Hli hauv Lub Lancet qhia tias delta ob npaug qhov kev pheej hmoo mus pw hauv tsev kho mob rau cov neeg laus, cov kws tshawb fawb tsis paub tias puas muaj tseeb rau menyuam yaus, hais tias Dr. Anthony Fauci, tus thawj coj hauv tebchaws kis tus kabmob.

Nws tau hais tias "Peb yeej tsis paub tam sim no tias cov menyuam muaj mob hnyav dua, tabsis peb tab tom saib xyuas nws,"

Txhawm rau tiv thaiv menyuam yaus, Fauci yaum niam txiv kom txhaj tshuaj tiv thaiv lawv tus kheej thiab menyuam yaus hnub nyoog 12 xyoos thiab tshaj saud. Raws li rau menyuam yaus tseem hluas rau kev txhaj tshuaj covid, "txoj hauv kev zoo tshaj kom lawv muaj kev nyab xeeb yog nyob ib puag ncig lawv los ntawm cov neeg uas tau txhaj tshuaj tiv thaiv."

KHN (Kaiser Health News) yog chav xov xwm thoob ntiaj teb uas ua rau sau xov xwm txog kev mob nkeeg. Ua ke nrog Kev Tshawb Xyuas Txoj Cai thiab Kev Xaiv Tsa, KHN yog ib qho ntawm peb qho kev ua haujlwm loj ntawm KFF (Kaiser Family Foundation). KFF yog lub koom haum muab txiaj ntsig tsis muaj txiaj ntsig muab cov ntaub ntawv ntawm kev noj qab haus huv rau hauv lub tebchaws.